Our research combines microbiology, microbial (meta)genomics and bioinformatics to analyse large-scale human gut microbiome population cohorts and study host-microbe associations, microbe-microbe interactions and microbial function in human health and disease.
We use statistical genetics, systems genomics and ecological modelling to integrate clinical, genomic and multi-omics data and investigate how commensals, pathobionts and the broader gut microbiota contribute to cardiometabolic, infectious, liver and other complex diseases, with a potential interest to translation toward precision medicine and microbiome-targeted interventions.
Our group works as part of consortia which include Nordic population cohorts and other publicly available large datasets. We also have an interest in larger biobank-scale cohorts to contextualise our research.
Our scientific interests have always been generalist and fundamental at heart, but a few topics are of particular current interest, through led projects in the lab or collaborations:
- Population and systems genomics of clinical, environmental and veterinary bacterial pathogens, including evolution, transmission and host adaptation.
- Human microbiome epidemiology in large cohorts, spanning metagenomics, metagenome-assembled genomes and multi-omics integration to map microbiome–host–environment interactions.
- Links between the gut microbiota, host genetics, lifestyle, diet and disease risk or progression in cardiometabolic and related conditions
- Effect of antibiotic and non-antibiotic medication on the gut microbiome and gut resistome dynamics.
- Exploring the human gut archaeome and its link with metabolic health
We are always extremely open to collaboration. If you are interested, please get in touch.